Table 1.
The diversity of α-chain of HLA-I and α- and β-chains of HLA-II is exemplified by the number of the named alleles and proteins (Based on December 2021, IPD-IMGT/HLA Database) 1,2.
| HLA Class I Alleles | HLA Class II Alleles | |||||||
|---|---|---|---|---|---|---|---|---|
| α-Chain | α-Chain | β-Chain | ||||||
| Genes | Alleles | Proteins | Genes | Alleles | Proteins | Genes | Alleles | Proteins |
| A | 7452 | 4355 | DRA | 32 | 5 | DRB1 | 3196 | 2152 |
| B | 8849 | 5343 | DRB2 | 1 | 0 | |||
| C | 7393 | 4095 | DRB3 | 423 | 314 | |||
| E | 310 | 121 | DRB4 | 215 | 139 | |||
| F | 50 | 7 | DRB5 | 171 | 131 | |||
| G | 102 | 35 | DQA1 | 442 | 205 | DQB1 | 2230 | 1407 |
| DQA2 | 40 | 11 | ||||||
| DPA1 | 406 | 173 | DPB1 | 1958 | 1223 | |||
1 Based on 2022 report found in ebi.ac.uk/ipd/imgt/hla/about/statistics/ (accessed on 1 July 2022); 2 Based on HLA Nomenclature @hla.alleles.org (accessed on 1 July 2022).