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. Author manuscript; available in PMC: 2022 Sep 22.
Published in final edited form as: Cell Rep. 2022 Aug 2;40(5):111156. doi: 10.1016/j.celrep.2022.111156

Figure 3. Mettl14 deficiency impairs the maturation of iNKT cells.

Figure 3.

(A) Representative staining of iNKT cells (CD69+CD1d/PBS57 tetramer+) at various developmental stages in the thymus of WT and T-Mettl14−/− mice.

(B and C) Quantification of percentages and cell numbers of stages 0, 1, 2, and 3 iNKT cells in WT and T-Mettl14−/− mice (n = 3–4).

(D) Intracellular staining of PLZF, T-bet, and RORγt in thymic iNKT cells of WT and T-Mettl14−/− mice.

(E and F) Quantification of percentages and cell numbers of NKT1, NKT2+NKTpre, and NKT17 subsets (n = 6). SEM is shown. *p < 0.05, **p < 0.01, ***p < 0.001.