Table 2.
Baseline lung function, ABG, and 6MWT functional parameters.
| Values | IPF (n = 53) | SSc-ILD (n = 31) | p-Value |
|---|---|---|---|
| Lung-function parameters | |||
| FVC (mL) | 3035.7 ± 836.2 | 2725.5 ± 655.6 | 0.080 |
| FVC (% pred) | 96.4 ± 13.9 | 98.7 ± 12.2 | 0.263 |
| FEV1 (mL) | 2488.5 ± 696.4 | 2301.6 ± 569.2 | 0.209 |
| FEV1 (% pred) | 98.6 ± 16.2 | 99.7 ± 13.3 | 0.748 |
| FEV1/FVC (%) | 82.6 ± 8.2 | 84.5 ± 5.2 | 0.329 |
| TLC (mL) | 4648.9 ± 1358.4 | 4263.9 ± 823.3 | 0.157 |
| TLC (% pred) | 79.5 ± 14.4 | 88.4 ± 15.4 | 0.022 |
| Diffusion parameters | |||
| DLCO (mmol/min/kPa) | 5.9 ± 1.8 | 6.4 ± 1.6 | 0.201 |
| DLCO (% pred) | 74.1 ± 17.6 | 83.7 ± 18.3 | 0.020 |
| KLCO (mmol/min/kPa/L) | 1.3 ± 0.3 | 1.4 ± 0.3 | 0.042 |
| KLCO (% pred) | 88.8 ± 24.2 | 71.2 ± 16.4 | <0.001 |
| ABGs | |||
| pH | 7.4 ±0.0 | 7.4 ±0.0 | 0.655 |
| pCO2 (mmHg) | 37.7 ± 5.5 | 37.1 ± 2.3 | 0.119 |
| pO2 (mmHg) | 67.8 ± 11.0 | 78.6 ± 8.6 | <0.001 |
| 6MWT | |||
| Distance (m) | 454.4 ± 103.1 | 449.3 ± 70.8 | 0.502 |
| Initial SpO2 (%) | 95.3 ± 2.9 | 94.9 ± 3.0 | 0.463 |
| Final SpO2 (%) | 88.8 ± 9.0 | 89.2 ± 10.8 | 0.407 |
| Initial HR (1/min) | 81.0 ± 13.9 | 84.4 ± 14.3 | 0.425 |
| Final HR (1/min) | 111.2 ± 19.7 | 106.5 ± 20.2 | 0.443 |
| Initial Borg score (0–10) | 0 (0–0) | 0 (0–0) | 0.885 |
| Final Borg score (0–10) | 2 (0–4) | 1.5 (1–3) | 0.924 |
Data are presented as mean ± SD, median (IQR). 6MWT, 6-minute walk test; ABGs, arterialized capillary blood gases; DLCO, diffusing capacity of the lungs for carbon monoxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; HR, heart rate; IPF, idiopathic pulmonary fibrosis; KLCO, transfer coefficient of the lung for carbon monoxide; pCO2; partial pressure of carbon dioxide; pO2, partial pressure of oxygen; SpO2, oxygen saturation; SSc-ILD, systemic-sclerosis-associated interstitial lung disease; TLC, total lung capacity. Statistically significant values are highlighted in bold.