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The mechanism of synergetic thermal therapy and radiation therapy. After heating to 45 °C several minutes before/during radiation, the radio-resistant of cancer cells are sensitized and the hypoxia degree of tumor is alleviated by the recruitment of oxygen. Thus, (1) increased damage to DNA by direct radiation or generated ROS is achieved, and (2) decreased expression of DNA repair-related proteins is realized. These two factors lead to the enhanced killing of cancer cells.
