. 2022 Aug 23;10(9):2055. doi: 10.3390/biomedicines10092055

Table 11.

List of patented formulations related to nanoparticles for oral drug delivery.

Patent Number	Assignee	Invention	References
WO2008073558A2	Johns Hopkins University, USA	The invention provided new orally bioavailable smart NPs for the delivery of poorly soluble drugs, showing improved pharmacokinetics and bioavailability.	[212]
WO2015067751A1	NanoSphere Health Sciences Inc., USA	Investigation disclosed the composition and development method for nutraceuticals encapsulated with phospholipid-based NPs by the emulsification method.	[214]
US20120003306A1	NancMega Medical Co., USA	The report disclosed a protein/peptide delivery system composed of chitosan and poly-y-glutamic acid (y-PGA). The NPs were suggested to enhance the epithelial permeability and thus are efficient for oral drug delivery.	[215]
WO2004098564A2	University of Illinois, USA	Reported the development of biodegradable NPs containing streptomycin with high loading efficiency of 50% or higher for tuberculosis treatment. The NPs can also contain other aminoglycoside drugs, which are a known substrate for the multidrug efflux mediated by P-glycoprotein (Pgp).	[216]
US7674767B2	Samyang Biopharmaceuticals Co., Korea	The invention described the composition and preparation of orally administrable NPs containing complexes of water-soluble drugs and counter-ion substances. The NPs enhanced drug entrapping and resistance against lipases, thereby increasing drug absorption.	[217]
WO2015023797A9	Northwestern University, USA	The patent disclosed the development and evaluation of drug-loaded nanostructures comprising an inorganic core and a lipid layer shell. The NPs showed potential in the treatment of cancer, vascular diseases and infectious diseases.	[218]
WO2014197640A1	South Dakota State University, USA	Disclosed the composition and preparation method of core-shell NPs. These NPs comprise food-grade proteins along with therapeutic agents suitable for pedatrics.	[219]
WO2007042572A1	Advanced In Vitro Cell Technologies S.A., Spain	The insertion described NPs comprising chitosan and heparin prepared by ionic gelation method. The NPs were stable in gastrointestinal fluids and presented excellent in vivo effectiveness and bioavailability.	[220]
CN102120781B	China Pharmaceutical University, China	The invention related to the preparation of oral insulin NPs. The NPs mainly contained N-amino acid chitosan as a carrier and insulin for the treatment of diabetes. The NPs were stable after oral administration with a better effect of reducing blood sugar in vivo.	[221]
US10420731B1	King Saud University, Saudi Arabia	The invention described the synthesis and preparation method of lignin NPs cross-linked and stabilized by citric acid for oral administration. The NPs improved the oral bioavailability of curcumin by increasing curcumin solubility and stability, sustaining its release, enhancing intestinal permeability, and inhibiting Pgp-mediated efflux.	[222]
WO2011034394A2	JW Pharmaceuticals Co., Korea	The invention reported the preparation of oxaliplatin-loaded NPs using supercritical fluid gas technology for oral chemotherapy.	[223]
WO2010015688A1	BioAlliance Pharma Co., USA	The patent disclosed the composition and preparation method of a chemotherapeutic formulation containing polymer and cyclic oligosaccharide capable of complexing and delivering anticancer drugs for effective cancer treatments.	[224]