Figure 9.

Effect of pharmacological inhibition of CBS/CSE on the induction of the Wnt/β-catenin pathway in Ade^CIN TS and Ade^CIN TSK organoids. (A,B) Western blot analysis of β-catenin, ACLY and p-ACLY in Ade^CIN TS in the presence of increasing concentrations of AOAA for 48 h. (C,D) Western blot analysis of β-Catenin, ACLY, and p-ACLY in Ade^CIN TSK in the presence of increasing concentrations of AOAA for 48 h. Data represent mean ± SEM of at least 4 independent experiments. * p < 0.05, ** p < 0.01 compared to control.