Table 1.

Body mass index (BMI), hyperhomocysteinemia (HHcy) cut-off was set at >15.0 μmol/L; high-sensitivity C-reactive protein (CRP) cut-off was set at <1.0 mg/L. Interferon-gamma (IFN-$\gamma$), interleukin (IL)-1$\beta$, IL-6, IL-8, IL-10, IL17A, IL22 and tumor necrosis factor alpha (TNF-α).

Clinical Data	NVU (N 45)	IVU (N 56)	p
Sex (Male/Female) (%)	38/62	42/58	0.79
Age (Years) (Median-Range)	81 (41–97)	76.5 (28–97)	0.35
BMI (Kg/m2) (Median-Range)	26.7 (21.0–40.2)	25.2 (20.2–42.5)	0.78
Diabetic (%)	N = 6 (13.3)	N = 11 (20.4)	0.46
Duration of ulcer (months) (Median-Range)	6.8 (3–48)	4 (3–48)	0.72
Size of ulcer (cm2) (Median-Range)	8.6 (1.5–53)	28 (3–140)	<0.0001
Depth of ulcer (% Grade 3)	N = 2 (4.4)	N = 17 (30.3)	0.0008
HHcy (% of positive subjects)	N = 7 (15.6)	N = 33 (58.9)	<0.0001
CRP (% of positive subjects)	N = 28 (62.2)	N = 38 (67.9)	0.58
IFN- $\mathsf{\gamma }$ (pg/mL) (Median-Range)	1.44 × 101 (1.11 × 100–3.76 × 102)	1.78 × 100 (1.02 × 100–8.21 × 101)	0.03
IL-1 $\mathsf{\beta }$ (pg/mL) (Median-Range)	7.49 × 104 (3.73 × 103–6.99 × 105)	7.53 × 104 (3.95 × 104–4.93 × 105)	0.80
IL-6 (pg/mL) (Median-Range)	1.84 × 104 (4.71 × 102–8.28 × 104)	1.75 × 105 (6.94 × 104–3.31 × 105)	0.0003
IL-8 (pg/mL) (Median-Range)	8.21 × 104 (2.07 × 104–8.94 × 105)	1.30 × 105 (3.89 × 104–1.86 × 106)	0.23
IL-10 (pg/mL) (Median-Range)	7.36 × 101 (4.61 × 100–3.12 × 102)	1.42 × 102 (6.26 × 101–6.02 × 102)	0.02
IL-17A (pg/mL) (Median-Range)	6.46 × 101 (2.38 × 100–2.01 × 102)	9.50 × 103 (5.49 × 101–7.84 × 103)	<0.0001
IL-22 (pg/mL) (Median-Range)	2.72 × 102 (1.05 × 100–8.34 × 102)	2.47 × 102 (1.03 × 100–1.67 × 104)	0.14
TNF- $\mathsf{\alpha }$ (pg/mL) (Median-Range)	3.75 × 102 (8.68 × 101–1.81 × 103)	1.59 × 103 (3.94 × 102–9.38 × 103)	0.0002