Table 1.
Summary of the 3 cases of patients with Peyronie’s disease who were treated with multimodal antioxidant therapy.
| # | Age/Years | Concomitant Diseases | Localization of the Penile Plaque | Plaque Measurements ( Length × Width × Thickness) and Volume of the Plaque (A) Prior and (B) After Therapy |
Typology of the Curvature (A) Prior and (B) After Therapy |
Penile Pain VAS Scale (Score 1 to 10) (A) Prior and (B) After Therapy |
IIEF Questionnaire Score (A) Prior and (B) After Therapy |
Duration of Therapy Up to Plaque Regression |
Description of the Administered Multimodal Therapy |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 34 years | Congenital lateral-left penile curvature (10-degrees) | Middle third | (A) 10.8 × 10.1 × 3.03 mm volume = 174 mm3 | (A) 40-degree left curvature | (A) score 2 | (A) score 26 | 2 years and 5 months |
orally: Silymarin 400 mg + Ginkgo biloba 250 mg + Propolis 600 mg + Bilberry 160 mg + Vitamin E 800 IU/once a day, for 29 months. + topically: Propolis creme/twice a day/for 29 months. * The patient refused peri-plaque penile injections |
| (B) No plaque detected | (B) 10-degree left penile curvature (previous condition = congenital lateral left penile curvature) | (B) score 0 (after 12 months) |
(B) score 26 | ||||||
| 2 | 32 years | lichen sclerosus, chronic prostatitis | Proximal third | (A) 16.4 × 8.27 × 3.09 mm volume = 219 mm3 | (A) 10-degree left curvature | (A) score 3 | (A) score 26 | 2 years and 9 months |
orally: Silymarin 400 mg + Ginkgo biloba 250 mg + Propolis 600 mg + Bilberry 160 mg + Vitamin E 800 IU/once a day, for 33 months. + topically: Propolis creme/twice a day/for 33 months. + peri-plaque penile injections: Pentoxifylline 100 mg (30 G needle) every 15 days for 6 months, and then monthly for 12 months, and then 1 injection every other month. for 12 months (total = 30 injections) |
| (B) No plaque detected | (B) None | (B) score 0 (after six months) |
(B) score 28 | ||||||
| 3 | 33 years | None | Middle third | (A) 20.6 × 15.2 × 4.42 mm volume = 724 mm3 + some small calcifications, the largest of which measured 1.9 × 4.1 mm | (A) 30-degree dorsal penile curvature | (A) score 2 | (A) score 26 | 3 years and 5 months |
orally: Silymarin 400 mg + Ginkgo biloba 250 mg + Propolis 600 mg + Bilberry 160 mg + Vitamin E 800 IU/once a day, for 41 months. + topically: Propolis creme/twice a day/for 41 months. + peri-plaque penile injections: Pentoxifylline 100 mg (30 G needle) every 15 days for 6 months, and then monthly for 12 months, and then 1 injection every other month. for 12 months (total = 30 injections) |
| (B) No plaque detected | (B) None | (B) score 0 (after six months) |
(B) score 27 |
* Abbreviations: IIEF score = Erectile function scoring; VAS = Pain scoring.