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IgG-A7 protection of K18-ACE2 mice expressing hACE2 infected with SARS-CoV-2 WT. The efficacy of IgG-A7 was assessed through survival (A) and viral load (B) analyses. Statistics were performed through Kaplan Meier survival analysis (Chi2 = 11.30, p = 0.0035) while viral load was performed by one-way ANOVA (F2,12 = 16.27) with Dunnett’s post hoc test (** p < 0.01; *** p < 0.001).
