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. 2022 Sep 3;10(9):2180. doi: 10.3390/biomedicines10092180

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MYH7B, miR-499, and SOX6 gene expression in cardiomyocytes. The levels of expressed miR-499 (A), MYH7B (B), and SOX6 (C) are evaluated by RT-qPCR in cardiomyocyte samples isolated from a subset of myectomies using LCM. Values are presented as boxes (min to max), and dots indicate single sample values. The distribution of miR and gene levels in HCM patients without HCM-associated mutations are presented in violet; those bearing mutations are in pink. The t-test was applied, and significant differences between HCM and CTRL are shown as *** p < 0.001. Significant difference between HCM with or without mutation is evaluated by the Mann–Whitney test, §§ p < 0.01.