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. 2022 Sep 3;10(9):2180. doi: 10.3390/biomedicines10092180

Figure 5.

Figure 5

MYHs, MyomiRs, and SOX6 expression in transfected cardiomyocytes from iPSC. The levels of expressed miR-499, MYH7B, MYH7, Mhrt, miR-208b, and SOX6 by RT-qPCR in cardiomyocytes differentiated from iPSC and transfected with miR-208a are shown at different time points (A). The expression of MYH7, Mhrt, miR-208b, and SOX6 determined in cardiomyocytes after transfection with miR-499 is plotted (B). The gene expression is presented as the ratio between 2^−ΔCt in treated vs. untreated cells (ratio control value =1 is indicated by dotted line where applicable). Amount of miR-499 released from transfected cardiomyocytes into culture supernatants is also shown (C). Values are presented as boxes (min to max), and dots indicate single sample values. ANOVA and Friedman tests are applied. p-value < 0.05 is considered significant and shown as *; p < 0.01 is indicated by **, and p < 0.001 by ***. Significant difference (p-value < 0.05 ) vs. untreated cells is indicated by §.