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. 2022 Sep 2;10(9):2166. doi: 10.3390/biomedicines10092166

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Internodal increased FC patterns: Significantly increased internodal connectivity in SCA2 patients as assessed by NBS analysis (FWE = 0.05) (bigger and smaller nodes). Labels represent bigger nodes that correspond to cerebellar and cortical regions showing significant correlations with MRIq (see Table 6). The brain network is visualised using the BrainNet Viewer (https://www.nitrc.org/projects/bnv/) [42] in axial (z), sagittal (x), and coronal (y) sections. MFC = medial frontal cortex; SMA = supplementary motor area; R = right; L = left.