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. 2022 Sep 11;12(9):1281. doi: 10.3390/biom12091281

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Plasma concentration of human AM in rats with mercury chloride-induced renal dysfunction increases independently of renal excretory function. (A) Plasma concentration vs time curve of human adrenomedullin (AM) during 60-min continuous intravenous infusion (0.1 µg/kg/min) in rats with renal dysfunction and normal rats. Closed circles, renal dysfunction rats induced by mercury chloride treatment (RD-Ag, top, n = 7); opened circles, normal renal function rats (NF, middle, n = 5); closed squares, renal dysfunction rats with bilateral renal blood flow blockage (RD-Bl, bottom, n = 3). (B) A positive correlation (R² = 0.6149, p < 0.01) between plasma concentration of human adrenomedullin at 60 min for intravenous infusion (AM C₆₀) and serum creatinine (sCr) in RD-Ag and NF rats. (C) Lack of correlation between plasma elimination half-life (T_1/2β) and serum creatinine (sCr) in RD-Ag and NF rats. Bars represent means ± SD.