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Partial (hybrid) EMT plays a key role in collective migration: clusters of mixed cancer cells in different stages of EMT and stemness invade and travel through the circulation to the premetastatic niche, where interaction with a variety of cells promotes MET and eventually successful seeding at the distant site. CSC: cancer stem cell; IC: immune cell; TAM: tumor-associated macrophages; CAF: cancer-associated fibroblast; MSC: mesenchymal stem cell.
