Table 3.

Multivariable Partial Proportional Odds Regression of Day 365 mRS on Baseline Characteristics, Unadjusted and Adjusted Results of Single Measure (n=1246) and Repeated Measures Analysis (n=1276)

Factor	Univariable single measure model [OR, σ2, (95% CI)]	Adjusted single measure model [OR, σ2, (95% CI)]	Univariable repeated measures model [OR, σ2, (95% CI)]	Adjusted repeated measures model [OR, σ2, (95% CI)]
Demographics
Male sex*	0.76†, 0.00, (0.70–0.81)	…	0.76†, 0.00, (0.75–0.77)	…
Age greater than 70 y*	2.46 † , 0.30, (1.59–3.79) ‡ 2.62 † , 0.04, (2.23–3.07) ‖ 2.94 † , 0.04, (2.56–3.38) ¶ 3.44 † , 0.11, (2.85–4.15) # 2.97 † , 0.91, (1.58–5.58)** 2.52, 1.75, (0.90–7.04) ††	…	2.12 § , 0.29, (1.29–3.48) ‡ 1.95 † , 0.00, (1.89–2) ‖ 2.3 † , 0.05, (1.90–2.79) ¶ 2.5 † , 0.03, (2.16–2.89) # 3.17 † , 0.32, (2.23–4.51)** 2.07, 1.02, (0.8–5.38) ††	…
Before stroke
Diabetes*	1.73†, 0.00, (1.61–1.87)	1.73†, 0.02, (1.45–2.06)	1.44†, 0.01, (1.28–1.61)	1.43†, 0.02, (1.18–1.74)
Coronary heart disease*	2.47†, 0.16, (1.79–3.4)	1.88†, 0.09, (1.37–2.57)	2.05†, 0.08, (1.56–2.69)	1.66†, 0.04, (1.30–2.12)
Ischemic stroke*	1.65†, 0.03, (1.32–2.06)	1.43§, 0.04, (1.11–1.85)	1.43§, 0.03, (1.13–1.8)	1.29, 0.03, (1.00–1.66)
Depression*	1.05, 0.03, (0.78–1.42)	0.92, 0.02, (0.70–1.22)	0.97, 0.01, (0.82–1.15)	0.88, 0.00, (0.76–1.00)
Independence*	0.09†, 0.00, (0.02–0.37)	0.15§, 0.01, (0.04–0.51)	0.12†, 0.00, (0.06–0.24)	0.18†, 0.00, (0.10–0.32)
Paid employment*	0.52‡‡, 0.02, (0.29–0.92)	0.75, 0.02, (0.52–1.09)	0.62, 0.03, (0.37–1.04)	0.86, 0.02, (0.60–1.22)
Partner*	0.71†, 0.00, (0.63–0.8)	0.87§, 0.00, (0.79–0.96)	0.77§, 0.00, (0.7–0.84)	0.92‡‡, 0.00, (0.85–1.00)
Living alone*	1.34§, 0.02, (1.11–1.61)	1.00, 0.00, (0.87–1.14)	1.23†, 0.00, (1.13–1.34)	0.97‡‡, 0.00, (0.95–0.99)
Current stroke (baseline)
Fluoxetine intervention*	1.06, 0.00, (0.97–1.15)	…	1.02, 0.00, (0.93–1.12)	…
Haemorrhagic stroke*	1.3, 0.08, (0.86–1.97)	1.35‡‡, 0.03, (1.03–1.75)	1.48§, 0.04, (1.14–1.93)	1.52†, 0.01, (1.33–1.74)
Treated in Australia*	1.47†, 0.01, (1.25–1.73)	…	1.28†, 0.01, (1.12–1.46)	…
Treated in New Zealand‡‡	1.83†, 0.13, (1.25–2.68)	…	1.77§, 0.05, (1.38–2.26)	…
PHQ‐9† Score	1.04§, 0.00, (1.02–1.06)	1.04†, 0.00, (1.01–1.07)	1.05§, 0.00, (1.03–1.06)	1.05§, 0.00, (1.03–1.07)
NIHSS Score	1.26 † , 0.00, (1.24–1.28) ‡ 1.26 † , 0.00, (1.18–1.36) ‖ 1.25 † , 0.00, (1.18–1.33) ¶ 1.24 † , 0.00, (1.23–1.24) # 1.15 † , 0.00, (1.10–1.19)** 1.13 † , 0.00, (1.11–1.16) ††	1.29 † , 0.00, (1.24–1.33) ‡ 1.3 † , 0.00, (1.24–1.37) ‖ 1.29 † , 0.00, (1.24–1.35) ¶ 1.25 † , 0.00, (1.23–1.28) # 1.15 † , 0.00, (1.12–1.19)** 1.13 † , 0.00, (1.12–1.15) ††	1.28 † , 0.00, (1.26–1.3) ‡ 1.28 † , 0.00, (1.22–1.34) ‖ 1.27 † , 0.00, (1.20–1.35) ¶ 1.29 † , 0.00, (1.27–1.3) # 1.2 † , 0.00, (1.20–1.21)** 1.16 † , 0.00, (1.12–1.2) ††	1.3 † , 0.00, (1.26–1.34) ‡ 1.3 † , 0.00, (1.25–1.36) ‖ 1.3 † , 0.00, (1.25–1.36) ¶ 1.3 † , 0.00, (1.30–1.31) # 1.2 † , 0.00, (1.19–1.22)** 1.15 † , 0.00, (1.11–1.19) ††
Time since stroke (reference: day 28)
Day 90	…	…	0.21 † , 0.00, (0.15–0.31) ‡ 0.48 † , 0.00, (0.46–0.5) ‖ 0.52 † , 0.00, (0.50–0.54) ¶ 0.45 † , 0.00, (0.43–0.46) # 0.78 † , 0.00, (0.68–0.89)** 2.37, 2.30, (0.67–8.31) ††	…
Day 180	…	…	0.12 † , 0.00, (0.06–0.21) ‡ 0.29 † , 0.00, (0.26–0.32) ‖ 0.35 † , 0.00, (0.28–0.45) ¶ 0.34 † , 0.00, (0.33–0.35) # 0.78 † , 0.00, (0.69–0.89)** 3.19, 6.21, (0.69–14.75) ††	…
Day 365	…	…	0.07 † , 0.00, (0.04–0.14) ‡ 0.25 † , 0.00, (0.21–0.29) ‖ 0.32 † , 0.00, (0.25–0.42) ¶ 0.36 † , 0.00, (0.31–0.42) # 1.22 † , 0.00, (1.09–1.38)** 5.34 ‡‡ , 17.75, (1.14–25.07) ††	…

Results are presented to 2 decimal places. Adjusted estimates were not provided for exogenous variables (age at stroke greater than 70 years, sex, fluoxetine intervention, location of treatment and time since stroke). NIHSS indicates National Institutes of Health Research Stroke Scale (higher scores indicates greater neurological impairment). NIHSS indicates National Institutes of Health Research Stroke Scale (higher scores indicates greater neurological impairment); OR, odds ratio; and PHQ‐9, 9‐item Patient Health Questionnaire (higher scores indicates more depressive symptoms).

^*Dummy Variable = 1 if true. Partner refers to participants who declared they were married or had a partner, relative to single participants. Living alone was relative to participants living in institutions or sharing a residence. Independence was defined as an estimated mRS score <2 before stroke. Haemorrhagic stroke was relative to ischemic strokes. Treatment in Australia and New Zealand was relative to Vietnam.

^† P<0.001.

^‡ mRS 0 vs 1 to 6: Odds ratio greater than 1 indicates higher odds of having an mRS greater than 0 (and vice‐versa).

^§ P<0.01.

^‖ mRS 0 to 1 vs 2 to 6: Odds ratio greater than 1 indicates higher odds of having an mRS greater than 1 (and vice‐versa).

^¶ mRS 0 to 2 vs 3 to 6: Odds ratio greater than 1 indicates higher odds of having an mRS greater than 2 (and vice‐versa).

^# mRS 0 to 3 vs 4 to 6: Odds ratio greater than 1 indicates higher odds of having an mRS greater than 3 (and vice‐versa).

^**mRS 0 to 4 vs 5 to 6: Odds ratio greater than 1 indicates higher odds of having an mRS greater than 4 (and vice‐versa).

^†† mRS 0 to 5 vs 6: Odds ratio greater than 1 indicates higher odds of having an mRS greater than 5 (and vice‐versa).

^‡‡ P<0.05.