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. 2022 Sep 7;12(9):738. doi: 10.3390/bios12090738

Figure 2.

Figure 2

An ECL-based sensing strategy and technology for the sensitive detection of biomarkers. (A) Insulin detection system combined with a co-reaction accelerator-involved redox reaction (reprinted with permission from [22], © 2019, Elsevier). (B) miRNA-21 detection system combined with a multiple co-reaction accelerator reaction and a 3D DNA walker-mediated signal amplification method (reprinted with permission from [31], © 2020, Elsevier). (C) miRNA-141 detection system combined with multiple ECL-RET reactions and a Pb2+-dependent DNAzyme-assisted target-recycling amplification (reprinted with permission from [38], © 2020, Elsevier). (D) Alpha-fetoprotein antigen (AFP) detection system using CuNCs as a near-infrared (NIR)-ECL luminophore and K2S2O8 as a co-reactant (reprinted with permission from [41], © 2022, American Chemical Society). CVD, chemical vapour deposition; HP, hollow porous; GCE, glassy carbon electrode; BSA, bovine serum albumin; THMS, triple-helix molecular switch; NF, nanoflower; QD, quantum dot; MB, magnetic bead; GCE, glassy carbon electrode; EDC, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride; NHS, N-hydroxysuccinimide; HWR, Fc-specific heptapeptide with HWRGWVC sequence; HS, hollow sphere.