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. 2022 Sep 16;10(9):2309. doi: 10.3390/biomedicines10092309

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of D2 DA antagonist pretreatment in the CeA of autistic rats on the conditioned place preference (CPP) test. Columns represent mean time spent in the treatment quadrant (±S.E.M.) during Habituation and Test sessions. Control: neurotypical/sham male Wistar rats receiving intraamygdaloid PBS (n = 8); VPA: intrauterine VPA-treated rats showing autistic-like behavior (n = 7); VPA + 10 ng OT: animals showing autistic-like behavior, microinjected with 10 ng OT (n = 7); VPA + D2 ANT + OT: animals with autistic-like behavior, microinjected with 10 ng OT and pretreated with 4 µg Sulpiride (n = 7); VPA + D2 ANT: animals with autistic-like behavior, treated with 4 µg Sulpiride (n = 7); * p < 0.05, for more explanations, see the text.