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Binding of mAbs to native pathogenic α-syn species in patient brain extract. The binding response of immobilized mAbs to α-syn in brain extractS from DLB (a) and MSA (b) patients was measured by SPR. A pan α-syn reactive antibody and mouse IgG1 (mIgG1) were used as controls. Results shown are the mean ± SEM of 2 (a) or 4 (b) independent studies.
