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. 2022 Sep 2;10(9):2168. doi: 10.3390/biomedicines10092168

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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mAb inhibition of oligomer toxicity in dopaminergic neurons. Cultures of primary rat dopaminergic neurons were exposed to toxic α-syn oligomers (α-synO; 0.5 μM) without or with mAbs (0.25 μM). Survival is expressed as the percentage of viable neurons compared to a control culture with vehicle only (CTL). BDNF was used as a positive control. Results shown are the mean ± SEM of 6 replicate cultures. A global analysis of the data was performed using one-way ANOVA followed by Dunnett’s multiple comparisons test. # p < 0.005 vs. CTL, * p ≤ 0.05 vs. α-synO, *** p ≤ 0.001 vs. α-synO. No statistically significant difference between BDNF and CTL or mAbs and CTL. Representative images of cultures with staining for neurons (MAP2, red) and nuclei (blue) are shown.