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. 2022 Sep 13;10(9):2267. doi: 10.3390/biomedicines10092267

Table 1.

Comparison between classical statistics and machine learning methods.

Classical Statistics Machine Learning
Approach Top-down (applied to data) Bottom-up (extracted by data)
Model Hypothesized by the researcher Auto-defined
Power of analysis Medium Usually High
Accuracy Medium It could be superior or inferior to that of classical statistics
Reliability The same data always provide the same results The results are affected by the initialization of parameters
Type of relationships among variables Often Linear, in general not complex Complex relationships
Interpretability Simple More complex