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. 2022 Aug 24;11(17):e022574. doi: 10.1161/JAHA.121.022574

Figure 1. Age‐associated characteristics of the MFG‐E8 knockout mouse.

Figure 1

A, Representative western blots of aortic MFG‐E8 (left panel). Quantitative data of western blots show aortic MFG‐E8 protein abundance (P<0.01 for main age effect, P<0.0001 for main genotype effect, P<0.01 for age×genotype, by 2‐way ANOVA). Graph (right panel) showing mean±SEM combined with individual data points for knockout and WT mice. ***P<0.001 by Bonferroni post‐hoc tests following 2‐way ANOVA. B, Morphometric analysis of the aortic IMT (P<0.0001 for main age effect, P<0.01 for main genotype effect, P<0.0001 for interaction by 2‐way ANOVA). Graph showing mean±SEM combined with individual data points for knockout and WT mice. **P<0.01; and ****P<0.0001 by Bonferroni post‐hoc tests following 2‐way ANOVA. IMT indicates intimal medial thickness; KO, knockout; MFG‐E8, milk fat globule–epidermal growth factor VIII; MW, molecular weight; and WT, wild‐type.