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. 2022 Aug 31;12(9):1211. doi: 10.3390/biom12091211

Figure 4.

Figure 4

Metoprolol elevates 7-DHC throughout the maternal brain. Pregnant mice were treated with 35 mg/kg MTP from E12 to E19. Dam brains were analyzed for sterol content by LC-MS/MS. Statistical significance: ** p < 0.01; *** p < 0.001; **** p < 0.0001 vs. vehicle treatment. Note that 7-DHC baseline levels in the vehicle-treated animals are different across the brain regions, and that a robust 7-DHC elevation is evident in all investigated brain regions. In the same brain regions, cholesterol levels were unchanged (Figure S9).