Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 31;12(9):1211. doi: 10.3390/biom12091211

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Maternal exposure to metoprolol results in strong elevation of 7-DHC and decreased desmosterol levels in the offspring brain. Pregnant mice were treated with 35 mg/kg MTP from E12 to E19. E19 brains were analyzed for sterol content by LC-MS/MS. Each symbol represents a sample originating from a single offspring brain. Blue fill = male embryos, pink fill = female embryos. Note the strong change in 7-DHC/CHOL (precursor/product) ratio. Statistical significance: *** p < 0.001; **** p < 0.0001.