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Maternal exposure to metoprolol results in strong elevation of 7-DHC and decreased desmosterol levels in the offspring heart. Pregnant mice were treated with 35 mg/kg MTP from E12 to E19. E19 hearts were analyzed for sterol content by LC-MS/MS. Each symbol represents a sample originating from a single offspring heart. Blue fill = male embryos, pink fill = female embryos. Note the strong change in 7-DHC/CHOL (precursor/product) ratio. Statistical significance: **** p < 0.0001.
