Table 1.

The two phases of DOMS adapted from the quad-phasic non-contact injury model [56].

Piezo2 Channelopathy Induced DOMS Injury Model
Primary injury phase
Repetitive superposition of compression forces due to fatiguing eccentric contractions
Fatigue and cognitive demand induced acute stress response
Acute stress derived energy depletion of the mitochondria in the affected proprioceptive terminals
Mechano-energetic impairment of Piezo2 and impairment of vesicular glutamate release
Painless Piezo2 channelopathy
Secondary injury phase
Harsher tissue damage due to impairment of Piezo2 with C-fiber contribution
Painful compression axonopathy