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Schematic illustration of crosslinking mechanisms of type I collagen with a physical crosslinker, (a) dehydrothermal treatment (DHT), and chemical crosslinkers, (b) aldehydes, (c) epoxy compounds, (d) NHS-activated carboxylic esters, (e), EDC and EDC/NHS, and (f) DPPA. These figures were adapted from Zhang et al. 2020 [112].
