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. 2022 Sep 8;10(9):2232. doi: 10.3390/biomedicines10092232

Figure 2.

Figure 2

Temporal changes in hemodynamic parameters and serum NO (nitrite and nitrate) levels in response to intraperitoneal infusion of l-NAME (10 mg/kg/day) for 14 days. Changes in (A) systolic blood pressure (SBP); (B) power density of low-frequency (LF) component of SBP signal; (C) plasma norepinephrine (NE) levels; (D) heart rate (HR); as well as (E) serum NO levels detected at different time points in the untreated group, or animals treated with i.p. infusion of saline or l-NAME. Data are presented as mean ± SD, n = 6 per group at each time interval. * p < 0.05 versus saline-treated group (pink or gray bars) in post hoc Tukey’s multiple-range test.