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Molecular mechanisms of radioresistance mediated by tumor cells. Radioresistance of tumor cells is a major barrier to successful cancer treatment. In order to evade cell death, tumor cells have developed a variety of strategies, including enhancing DNA repair, activating cell-cycle checkpoints, regulating the self-renewal and differentiation of cancer stem cells, enhancing cellular metabolism, regulating the activities of autophagy, and regulating the expression of non-coding RNA.
