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MDR1 and BCRP overexpression and EGFR signalling pathway activation following LR induction. (A–C) qRT-PCR, western blotting, and immunofluorescence analysis demonstrated that MDR1 and BCRP expression was upregulated following LR induction. Scale bars, 100 μm. (D) Western blotting revealed that EGFR and its downstream MEK/ERK and PI3K/AKT pathways were markedly activated following LR induction. **p < 0.01. ***p < 0.001.
