Table 3.
Changes in quality-of-life scores.
| QOL Score LS Mean (95% CI) |
Change from Baseline LS Mean (95% CI) |
p-Value vs. Baseline |
|
|---|---|---|---|
| Functional scales | |||
| Physical functioning | |||
| Pre-HN-PIT | 88.1 (80.7–95.6) | - | - |
| 4 weeks | 90.4 (83.0–97.8) | 2.2 (−2.9–7.3) | 0.347 |
| Role functioning | |||
| Pre-HN-PIT | 85.2 (70.9–99.4) | - | - |
| 4 weeks | 90.7 (76.5–105.0) | 5.6 (−12.6–23.7) | 0.500 |
| Emotional functioning | |||
| Pre-HN-PIT | 89.8 (80.4–99.2) | - | - |
| 4 weeks | 86.1 (76.7–95.5) | −3.7 (−10.9–3.5) | 0.272 |
| Cognitive functioning | |||
| Pre-HN-PIT | 87.0 (73.7–100.4) | - | - |
| 4 weeks | 87.0 (73.7–100.4) | 0.0 (−11.1–11.1) | >0.999 |
| Social functioning | |||
| Pre-HN-PIT | 88.9 (77.7–100.1) | - | - |
| 4 weeks | 92.6 (81.4–103.8) | 3.7 (−10.3–17.7) | 0.559 |
| Global health status | |||
| Global health status/QoL | |||
| Pre-HN-PIT | 68.5 (51.7–85.3) | - | - |
| 4 weeks | 61.1 (44.3–77.9) | −7.4 (−20.8–6.0) | 0.237 |
| Domain scales | |||
| Pain | |||
| Pre-HN-PIT | 21.3 (5.1–37.5) | - | - |
| 4 weeks | 25.9 (9.8–42.1) | 4.6 (−6.5–15.8) | 0.366 |
| Swallowing | |||
| Pre-HN-PIT | 30.6 (10.7–50.5) | - | - |
| 4 weeks | 25.0 (5.1–44.9) | −5.6 (−31.0–19.9) | 0.628 |
| Sense problems | |||
| Pre-HN-PIT | 9.3 (−7.7–26.2) | - | - |
| 4 weeks | 7.4 (−9.6–24.4) | −1.9 (−6.1–2.4) | 0.347 |
| Speech problems | |||
| Pre-HN-PIT | 34.6 (18.8–50.3) | - | - |
| 4 weeks | 34.6 (18.8–50.3) | 0.0 (−26.7–26.7) | >0.999 |
| Trouble with social eating | |||
| Pre-HN-PIT | 33.3 (14.2–52.4) | - | - |
| 4 weeks | 26.9 (7.8–46.0) | −6.5 (−17.5–4.5) | 0.211 |
| Trouble with social contact | |||
| Pre-HN-PIT | 9.6 (−4.0–23.3) | - | - |
| 4 weeks | 16.3 (2.6–29.9) | 6.7 (−6.1–19.5) | 0.264 |
| Less sexuality | |||
| Pre-HN-PIT | 18.5 (−6.5–43.6) | - | - |
| 4 weeks | 13.0 (−12.1–38.0) | −5.6 (−14.6–3.5) | 0.195 |
QOL, quality of life; LS mean, least square mean; 95% CI, 95% confidence interval; HN-PIT, head and neck photoimmunotherapy.