. 2022 Sep 7;11(18):2790. doi: 10.3390/cells11182790

Table 1.

MAM related proteins identified by VLGR1 TAPs in HEK293T and hTERT-RPE1 cells proteins associated with: Ca²⁺ homeostasis, orange; lipid metabolism, yellow, MAM structure, gray.

Gene	Protein	Protein Function	Reference	HEK	RPE1
*ACSL4*	Long-chain-fatty-acid—CoA ligase 4	lipid biosynthesis & fatty acid degradation	[29]	+	−
*AIFM1*	Mitochondrial apoptosis-inducing factor 1	apoptosis, mito. morphology	[30]	+	−
*AMFR*	Autocrine motility factor receptor	ubiquitination	[31]	+	−
*BCAP31*	B-cell receptor-associated protein 31	apoptosis	[32]	+	−
*BSG*	Basigin	regulatory component of γ-secretase	[33]	+	+
*CANX*	Calnexin	calcium pump	[34]	+	+
*CISD2*	CDGSH iron sulfur domain 2	calcium homeostasis	[35]	+	−
*ERLIN2*	Erlin-2	targets IP3Rs for degradation	[36]	+	+
*ERP44*	ER resident protein 44	ER protein retention	[37]	+	−
*G6PC3*	Glucose-6-phosphatase 3	gluconeogenesis	[38]	+	−
*HSPA5*	Heat shock protein 5	chaperone, ER stress	[39]	+	+
*HSPA9*	Mitochondrial heat shock protein 9	chaperone, binds VDAC	[40]	+	+
*LCLAT1*	Lysocardiolipin acyltransferase 1	chardolipin acyl chain remodeling	[41]	+	−
*LMAN1*	ERGIC-53	mannose-specific lectin	[42]	+	−
*MAVS*	Mito. antiviral-signaling protein	activation of NF-kb/IRF3	[43]	+	+
*P4HB*	Protein disulfide-isomerase	ER protein retention	[44]	+	+
*PIGN*	Phosphatidylinositol glycan anchor biosynthesis, class N	glycolipid, GPI syntheses	[41]	+	−
*PSEN1*	Presenilin-1	component of γ-secretase	[45]	+	−
*PSEN2*	Presenilin-2	component of γ-secretase	[45]	+	−
*PTDSS1*	Phosphatidylserine synthase 1	phospholipid metabolism	[46]	+	−
*PTDSS2*	Phosphatidylserine synthase 1	phospholipid metabolism	[46]	+	−
*RHOT1*	Mitochondrial Rho GTPase 1	mitochondrial trafficking	[47]	+	−
*RTN2*	Reticulon-2	formation of tubular ER	[48]	+	+
*RTN4*	Reticulon 4, neurite outgrowth inhibitor, Nogo-A	ER-mitochondria tethering, membrane trafficking	[21]	+	+
*SCD*	Stearoyl-CoA desaturase	fatty acid transport	[49]	+	+
*SIGMAR1*	Sigma-1 receptor, SR1	chaperone, lipid transport, Ca²⁺ signaling	[39]	+	+
*SLC27A4*	Long-chain fatty acid transport protein 4	fatty acid transport	[50]	+	+
*SOAT1*	Sterol O-acyltransferase 1	cholesterol metabolism	[42]	+	+
*VAPB*	VAMP-associated protein	ER-mitochondria tethering	[27]	+	−
*VDAC1*	Voltage-dependent anion-channel 1	ion exchange, Ca²⁺ transport	[40]	+	+
*VDAC2*	Voltage-dependent anion-channel 2	ion exchange, Ca²⁺ transport	[51]	−	+
*WSF1*	Wolframin, ER, transmembrane	Ca²⁺ transport, ER stress	[52]	+	−