Figure 2.

Schematic diagram of lipid metabolism reprogramming in metastatic tumor cells. Extracellular FAs could be transported across the membrane by CD36 and FABPs. The entry of FAs into mitochondria for FAO is controlled by CPT1. ACSL1 catalyzes the conversion of citrate to substrates for lipid synthesis. ACC and FASN are key enzymes in the biosynthesis of palmitate. Then, ELOVL6 and SCD1 facilitate the conversion of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA). Excess lipids can be stored in the forms of LD, which cores are CE and TG. Under stress conditions, LDs could be degraded by lipolysis and lipophagy to generate energy.