Figure 2.

Schematic representation of drugs directly or indirectly targeting MYCN. Drugs are marked in red and reported as class, named on mechanism of action. Abbreviation: MDM2, murine double minute 2; PI3K, Phosphoinositide 3-kinases; PI3Ki, Phosphoinositide 3-kinases inhibitor; BETi, bromodomain and extra-terminal domain family inhibitor; BRD4, bromodomain-containing protein 4; mTORC1, mammalian target of rapamycin complex 1; mTORC2, mammalian target of rapamycin complex 2; mTORi, mammalian target of rapamycin inhibitor; PROTACs, proteolysis-targeting chimeras; MIZ1, MYC-interacting zinc-finger protein 1; HDAC, histone deacetylase; HDACi, histone deacetylase inhibitor; E3, E3 ubiquitin ligase; E2, E2 ubiquitin-conjugating enzyme; AURKA, Aurora kinase A; AURKAi, Aurora kinase A inhibitor; Ub, ubiquitin.