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. 2022 Sep 7;11(18):2799. doi: 10.3390/cells11182799

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Wild-type ADMSCs exerted proangiogenic and anti-inflammatory effects on the grafts: (a–c) histology analysis of the graft at 7 days after transplantation of AFT (upper panel and inset) and AFT-ADMSC (bottom panel and inset) for (a) H&E, (b) immunohistochemistry for CD31, and (c) immunohistochemistry for F4/80; (d–f) histology analysis of the graft at 180 days after transplantation of AFT (upper panel and inset) and AFT-ADMSC (bottom panel and inset) for (d) H&E, (e) immunohistochemistry for CD31, and (f) immunohistochemistry for F4/80, scale bar = 100 µm; (g) quantitative measurement of CD31-positive vessels for AFT and AFT-ADMSC (left graph) and F4/80-positive area/graft (right graph) at 7 days post-transplantation; (h) quantitative measurement of CD31-positive vessels for AFT and AFT-ADMSC (left graph) and F4/80-positive area/graft (right graph) at 180 days post-transplantation. Quantification was performed using Image J software; * p < 0.05, n = 7.