Table 3.
Cox proportional hazards regression model for cutaneous melanoma (CM)-specific survival and the total effects for the pan-immune-inflammation value (PIV) and neutrophil-to-lymphocyte ratio (NLR) adjusted for potential confounders.
| Model and Variables | p-Value | Hazard Ratio (HR) | 95% Confidence Interval |
|---|---|---|---|
| PIV model | |||
| PIV 2nd third (219.73 ≤ 393.73) | 0.6476 | 0.87 | 0.48 to 1.57 |
| PIV 3rd third (>393.73) | 0.2553 | 1.36 | 0.80 to 2.30 |
| Stage II | 0.2159 | 1.66 | 0.75 to 3.68 |
| Stage III | 0.0002 | 3.72 | 1.85 to 7.46 |
| CM subtype-ALM | 0.7185 | 1.17 | 0.49 to 2.80 |
| -LMM | 0.5596 | 1.83 | 0.24 to 14.11 |
| -NM | 0.8061 | 1.07 | 0.61 to 1.88 |
| -Others | 0.2259 | 0.64 | 0.31 to 1.31 |
| Age | 0.0099 | 1.02 | 1.00 to 1.04 |
| pT (1–4) | <0.0001 | 1.17 | 1.08 to 1.26 |
| Ulceration | 0.0180 | 1.84 | 1.11 to 3.04 |
| NLR model | |||
| NLR 2nd third (2.02 ≤ 3) | 0.7537 | 0.91 | 0.51 to 1.62 |
| NLR 3rd third (>3) | 0.2543 | 1.37 | 0.80 to 2.33 |
| Stage II | 0.2239 | 1.64 | 0.74 to 3.66 |
| Stage III | 0.0002 | 3.79 | 1.90 to 7.57 |
| CM subtypes-ALM | 0.6600 | 1.21 | 0.51 to 2.88 |
| -LMM | 0.4884 | 2.06 | 0.27 to 15.87 |
| -NM | 0.6541 | 1.14 | 0.65 to 1.99 |
| -Others | 0.2472 | 0.66 | 0.32 to 1.34 |
| Age | 0.0089 | 1.02 | 1.00 to 1.04 |
| pT (1–4) | <0.0001 | 1.16 | 1.08 to 1.25 |
| Ulceration | 0.0145 | 1.87 | 1.13 to 3.09 |
Potential confounders in gray.