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. 2022 Sep 16;11(18):2891. doi: 10.3390/cells11182891

Table 1.

Systematic parameters in pigs with a 16-week metabolic syndrome (MetS) untreated or treated with elamipretide (ELAM).

Parameter Lean Mets Mets + ELAM
Body weight (Kg) 68 ± 6.0 92.3 ± 4.3 * 93.1 ± 3.4 *
Glucose (mg/dL) 111 ± 3.5 108.1 ± 26.5 109.3 ± 24.3
Fasting Insulin (µU/mL) 0.4 ± 0.008 0.9 ± 0.2 * 0.7 ± 0.1 *
HOMA-IR score 0.6 ± 0.1 1.3 ± 0.2 * 1.2 ± 0.1 *
Total cholesterol (mg/dL) 72.3 ± 6.9 564.2 ± 68.3 * 603.0 ± 62.3 *
HDL cholesterol (mg/dL) 42.9 ± 1.4 164.8 ± 28.1 * 130.3 ± 9.8 *
LDL cholesterol (mg/dL) 29.1 ± 2.7 389.1 ± 48.9 * 390.3 ± 50.1 *
Triglycerides (mg/dL) 7.4 ± 0.6 12.5 ± 2.1 * 13.2 ± 1.8 *
Creatinine (mg/dL) 1.67 ± 0.24 1.45 ± 0.20 1.62 ± 0.40

HOMA-IR: hemostasis model assessment of insulin resistance, HDL: high-density lipoprotein, LDL: low-density lipoprotein, * p < 0.05 vs. lean.