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. 2022 Sep 9;14(18):4398. doi: 10.3390/cancers14184398

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of FXR overexpression on lung metastasis in a xenograft mouse model. (A) Experimental timeline. (B) The effects of control and FXR-O on the size and growth of tumors were observed using bioluminescent imaging with an in vivo imaging system (IVIS). (C) The luminescence intensity of photons emitted from each tumor was quantified (Log). (D) The animal survival rate was observed over the 42-day experimental period shown by a Kaplan-Meier survival curves. (E) Body weights were measured during the experimental period. * p < 0.05 compared to the control group.