Figure 5.

The effect of FXR overexpression on cholesterol biosynthesis-related protein expression in lung tissues of the xenograft model. (A) Lung tumors were observed by hematoxylin and eosin staining. Scale bar = 1 mm and 50 μm. (B) Immunohistochemical analysis of MMP2, SREBP2 and HMGCR expression in lung tissues from the control and FXR-O groups. Scale bar = 50 μm. (C) MMP2, p-AMPK, AMPK, SREBP2 and HMGCR protein expression was measured by Western blotting analysis. (D) The relative quantitative analysis of these proteins was shown by bar graphs. * p < 0.05; ** p < 0.01 compared to the control group. The original blots are shown in Figure S6B.