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. 2022 Sep 9;14(18):4398. doi: 10.3390/cancers14184398

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of FXR overexpression combined with atorvastatin treatment on the invasion and angiogenesis of T24 cells. (A) Transwell invasion assays were performed in control and FXR-O T24 cells treated with or without atorvastatin. The lower panel shows the relative migration rate. (B) Tube formation assays were performed in control and FXR-O T24 cells treated with or without atorvastatin. The number of branch points and tube length of endothelial cell networks were analyzed. The quantitative results of the analysis of relative branch point numbers and tube lengths were shown below. * p < 0.05; ** p < 0.01; compared to the control group. # p < 0.05 compared to the control + atorvastatin group. $ p < 0.05 compared to the FXR-O group. Scale bar = 200 μm.