Table 2.

Percent change MRI variables after 3 weeks of therapy.

MRI Variable	Full (n = 103)			Control (n = 75)			Pembro (n = 28)
	pCR (n = 30)	Non-pCR (n = 73)	p	pCR (n = 15)	Non-pCR (n = 60)	p	pCR (n = 15)	Non-pCR (n = 13)	p
ADC_mean	18.9 (4.4, 23.6)	10.2 (2.6, 15.3)	0.0076	15.8 (3.1, 22.9)	10.3 (5.1, 15.8)	0.13	19.2 (8.2, 23.1)	3.5 (−2.4, 14.7)	0.041
ADC_min	28.0 (5.9, 54.7)	12.6 (−0.7, 24.6)	0.0075	23.4 (−2.7, 53.0)	14.1 (−0.8, 19.4)	0.15	29.7 (10.6, 56.5)	9.6 (−0.2, 20.8)	0.029
ADC_5	20.0 (−1.1, 32.8)	8.0 (0, 17.5)	0.0297	18.2 (−6.5, 33.5)	9.1 (−0.3, 19.4)	0.35	23.5 (4.7, 32.1)	6.1 (4.6, 10.5)	0.0799
ADC_15	17.3 (0.3, 27.6)	9.6 (2.4, 16.0)	0.039	14.6 (0.6, 26.7)	9.9 (3.3, 17.2)	0.47	22.2 (2.2, 28.3)	7.8 (1.1, 11.2)	0.040
ADC_25	17.9 (3.1, 29.7)	8.6 (2.4, 15.4)	0.014	15.7 (1.8, 23.2)	10.2 (3.6, 16.2)	0.25	23.6 (5.3, 31.4)	5.2 (0, 11.9)	0.025
ADC_50	18.0 (3.0, 23.5)	10.1 (3.2, 15.5)	0.048	13.2 (0.2, 23.8)	10.4 (3.8, 15.5)	0.34	19.5 (7.1, 22.996)	2.9 (−1.2, 14.2)	0.098
ADC_75	14.9 (1.5, 23.7)	8.5 (1.8, 15.6)	0.052	14.6 (1.1, 25.3)	8.9 (2.8, 14.9)	0.19	15.2 (5.5, 21.1)	1.8 (−3.6, 17.4)	0.196
ADC_95	15.0 (1.1, 20.4)	7.3 (0, 14.0)	0.087	18.6 (7.9, 22.6)	7.5 (1.5, 14.3)	0.027	6.01 (0.5, 16.1)	0.8 (−4.98, 12.5)	0.39
ADC_max	6.3 (−1.2, 11.8)	7.4 (−1.7, 13.8)	0.85	10.8 (1.8, 14.8)	7.5 (−2.2, 14.6)	0.53	3.8 (−5.5, 9.7)	3.8 (0.7, 9.9)	0.82
FTV	−56.97 (−83.9, −19.98)	−31.5 (−58.4, −3.8)	0.016	−59.9 (−82.0, −14.2,)	−30.6 (−54.2, −2.7)	0.056	−47.7 (−83.4, −20)	−46.3 (−64.6, −8.99)	0.34