Table 1.
MRI protocols used to monitor TH-MYCN tumor volumes.
| Sequence | Purpose | Parameters | Number of Mice in Group Treated with | |
|---|---|---|---|---|
| JQ1 | Vehicle | |||
| FSE T2w | Tumor detection, delineation and volume measurement | SR: 156 µm × 161 µm × 1500 µm, Sl: 16, TE: 68 ms, TR: 5000 ms, ET: 8, AVG: 3, SD: 7 min 45 s, RG ON | 9 | 6 |
| FSE T1w | Tumor detection, delineation and volume measurement | SR: 156 µm × 159 µm × 1500 µm, Sl: 16, TE: 11 ms, TR: 1000 ms, ET: 4, AVG: 4, SD: 4 min 12 s, RG ON | ||
| MEMS | T2 relaxometry map | SR: 156 µm × 208 µm × 1500 µm, Sl: 16, fTE: 15 ms, NOE: 10, TR: 3000 ms, AVG: 1, SD: 9 min 36 s, RG ON | ||
| MGE | T2* relaxometry map | FLASH, SR: 313 µm × 313 µm × 1500 µm, Sl: 16, fTE: 4 ms, TR: 600 ms, NOE: 10, AVG: 1, SD: 1 min 16 s, RG ON | ||
SR: spatial resolution, Sl: number of slices, TE: echo time, TR: repetition time, ET: echo train, AVG: number of averages, SD: scan duration, RG: respiratory gating, fTE: first echo time, NOE: number of echoes, FLASH: fast low angle shot, NE: number of experiments, TRes: time resolution.