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. 2022 Sep 15;14(18):4478. doi: 10.3390/cancers14184478

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical analysis of TFF1 expression in normal mucosa and in CRC tissue. (A) Overview of an area containing normal mucosa (N) and the adjacent cancer tissue (C). Arrows mark TFF1-positive goblet cells; (B) localization of TFF1 in goblet cells of normal mucosa (N) (arrows); (C) loss of TFF1 expression in adjacent cancer (C) tissue; (D) a mixed pattern of carcinoma tissue staining with both positive (arrows) and negative areas; (E) a mucinous carcinoma area positive for TFF1 staining (arrows); (F) normal mucosa stained for TFF1 in goblet cells (arrows).