Table 7.

Comparison of the relative expression patterns of selected microRNAs in patients with Turner syndrome.

miRNA	miRNA Sequencing			Validation Results by qRT-PCR
	Up/Down	Fold Change	p-Value	Up/Down	Fold Change	p-Value
hsa-miR-16-5p	Down	0.099	0.058	Up	1.673	0.811
hsa-miR-20a-5p	Up	1.014	0.987	Up	1.843	0.447
hsa-miR-29a-3p	Down	0.141	0.197	Up	9.788	0.021
hsa-miR-30b-5p	Down	0.240	0.284	Up	5.380	0.119
hsa-miR-99b-3p	Up	14.081	0.171	Down	0.175	0.011
hsa-miR-151a-5p	Down	0.524	0.248	Up	1.008	0.991
hsa-miR-200b-3p	Down	0.692	0.671	Down	0.439	0.296
hsa-miR-423-3p	Up	1.803	0.474	Down	0.345	0.363
hsa-miR-941	Up	5.138	0.235	Down	0.207	0.064
hsa-miR-4492	Up	13.250	0.058	Down	0.286	0.107
hsa-miR-4516	Up	7.254	0.044	Up	2.663	0.022
hsa-miR-7847-3p	Up	12.252	0.212	Down	0.286	0.026

These patterns were obtained by using miRNA sequencing and validated by using qRT-PCR; Fold change is presented as miRNA expression in patients with Turner syndrome compared to the control individuals. Abbreviations: Hsa, Homo sapiens; miR, microRNA; qRT-PCR, quantitative real-time polymerase chain reaction.