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The NEAT1 gene gives rise to two isoforms with identical 5′ sequences. The paraspeckle-independent NEAT1_1 undergoes canonical 3′ polyadenylation whilst the blocking of 3′ polyadenylation via competitive binding of hnRNPK to the CFIm complex yields the paraspeckle-essential NEAT1_2. The recruitment of paraspeckle proteins to the hydrophilic and hydrophobic regions of NEAT1_2 leads to phase-separated paraspeckles.
