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Nucleocytoplasmic transport of NEAT1_1 enhances the Warburg effect via the binding to glycolytic enzymes. TDP-43, ARS2, and CFIm promote the canonical 3′ polyadenylation of NEAT1_1, which can then bind to pinin for nuclear export to the cytoplasm. Once in the cytoplasm, NEAT1_1 can bind with the glycolytic enzymes PGK1 (A), PGAM1 (B), and ENO1 (C) to enhance glycolytic flux, and hence the Warberg effect, in transformed cells.
