Figure 3.

IAL suppresses midbrain inflammatory responses and increases striatal dopamine and its metabolite levels in MPTP-induced PD mice. (A–C) The expression of pro-inflammatory mediators (IL-6, IL-1β and TNF-α) in the midbrain and serum was detected with the ELISA method. (D) Levels of dopamine and its metabolites (DOPAC and HVA) in the striatum were detected by HPLC. Results are shown as means ± SEM (n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.001 stand for biologically significant differences.