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. 2022 Aug 28;9(9):1305. doi: 10.3390/children9091305

Figure 5.

Figure 5

Changes in insulin secretion by primary islet cell groups (n = 3) responding to GABA and bicuculline (Bic) quantified by ELISA assays. (A) In 2 mM glucose media, the insulin secretion levels by the control islets increased with exogenous addition of GABA, and decreased with bicuculine. (B) In 16 mM glucose media, the insulin secretion levels by control islets increased with exogenous addition of GABA, and decreased with bicuculine. (C) No comparisons differed significantly, except for normal (N) versus 10 mM Tolbutamide (Tol) (p = 0.0448). (D) In 16 mM glucose medium for IH-treated islets, secretion increased with exogenous addition of GABA and decreased with bicuculine. * indicates p < 0.05, *** indicates p < 0.001 and **** indicates p < 0.0001. Comparisons between N vs. Tol were not indicated here; however, the addition of Tol elevated the insulin levels significantly at p < 0.05 when compared with each baseline N in each panel, except for (B) (p = 0.1294).