Figure 5.

Knockdown of hsa_circ_0062682 in SNU-449 cell line induces profound changes on the transcriptomic level. (A) Pathway enrichment analysis of upregulated (red colour) and downregulated (blue colour) pathways. Each node (circle) represents a pathway and edges represent shared genes by the connected pathways. Annotations of clusters of similar pathways representing major biological themes are provided above clusters; (B) heatmap of top 20 most upregulated and top 20 most downregulated genes in a stable KD of hsa_circ_0062682 in SNU-449 cell line, heatmap legend consists of log2 transformed expression values; (C) volcano plots from Enrichr analysis of enriched gene sets in KEGG pathways and in (D) the TRRUST database of transcription factors, made by Appyter. Blue dots represent significantly enriched gene sets, grey dots represent not enriched gene sets.