Table 3.

Assessment tests on PD disease progression [26].

Outcomes	Assessments
Skeletal muscle strength	Manual muscle testing (MMT) Assessed based on Medical Research Council (MRC) grading scale, ranging from 0 to 5 Handheld dynamometry (HHD) Measured in Newtons (N) and maximum isometric contraction values
Vital capacity	Recommended frequency: every 3–6 months [60] Performed in the upright and supine positions Formal pulmonary function testing (PFT) should be performed for patients with diaphragmatic weakness
Functional exercise capacity	6 min walk test Performed indoors along a 30 m long, straight and flat corridor. Count the laps to estimate the distance covered. Record patient’s dyspnea and fatigue
Quality of life	The Short Form 36 (SF36) Health Survey Assessed the changes in QoL in both physical health and mental health domains
Hearing	Audiology assessment Performed at baseline and then as clinically indicated
Laboratory tests	Performed every 3 months in the first year of diagnosis, followed by monitoring every 6 months in the following years if stable on ERT CK Reduction in CK level indicates response to treatment GAA antibody titers High and sustained antibody titers (HSAT) correlate with poor response to ERT in IOPD