Skip to main content
. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Neuropharmacology. 2022 Feb 14;208:108997. doi: 10.1016/j.neuropharm.2022.108997

Figure 2.

Figure 2.

LC and CeA circuitry in stress and alcohol use disorder. The LC sends noradrenergic projections to the CeA, while the CeA sends GABAergic and CRF-positive projections to the LC. During stress or alcohol withdrawal, LC activity increases and sends enhanced noradrenergic input to the CeA. This in turn increases GABA/CRF neuron activity in the CeA resulting in a feedforward-loop causing enhanced LC and CeA activity in stress and alcohol withdrawal. This enhanced activity contributes to an increase in both anxiety-like behaviors and alcohol consumption in rodents.